Current Projects

Continued Development and Maintenance of the CYCORE Software System (UCSD, PI: K.Patrick)
(Project Dates: 04/01/2014 – 02/28/2019, R01CA177996, National Cancer Institute, NIH)

In this grant from the National Cancer Institute, we seek to improve the scalability and performance, expand capability for new sensors and address fault tolerance and self-healing, incorporate new algorithms for the detection and analysis of CER outcomes in cancer, improve security, privacy and data sharing capabilities of CYCORE, and develop and implement a model for sustainability.

We also plan to support an increasingly expanding community of researchers and clinicians in a variety of cancer care and research settings. In particular, we see the opportunity to continue to engage users at M.D. Anderson Cancer Center (MDACC) while expanding the user base to researchers affiliated with research networks such as the NCI Community Oncology Research Program (N-CORP), community based oncology treatment centers and other cancer research centers nationally. R01CA177996, National Cancer Institute, NIH

Sensor-Assisted Prevention of Dehydration in Head and Neck Cancer Patients (MDA, PI: S. Peterson)
(Project Dates: 09/2/2013 – 8/31/2016 R01CA177914, National Cancer Institute, NIH)

While head and neck cancer (HNC) is often curable, primary radiation therapy (RT) is nonetheless challenging with concomitant serious side effects. Up to 80% of patients experience moderate to severe oral mucositis (painful inflammation and ulceration of the mucous membranes), which makes it nearly impossible to drink sufficient fluids. As a result, up to 27-32% of HNC patients may be admitted for emergency care during RT due to dehydration. Hospitalizations due to dehydration (and related costs) are largely preventable, provided at-risk patients can be identified early so that intravenous fluid rehydration can take place. Currently, clinicians assess HNC RT patients once per week during their standard clinic visits; however, dehydration can develop rapidly, and often does between those visits. Previously, we demonstrated that it is feasible to systematically and accurately collect dehydration risk data (weight, blood pressure [BP], pulse, and related symptoms) from HNC RT patients using home-based biometric and other sensor devices integrated within CYCORE, and that we could deliver these data on a daily basis to clinicians for their review (insert link to JNCI paper).

This grant from National Cancer Institute will evaluate whether use of the CYCORE system (versus standard care) reduces hospital and ER admissions due to dehydration, and whether associated costs (modeled upon national data) are reduced. Based on user (clinician) input, we have updated our system to provide streamlined data interpretation displays for the clinicians. We will recruit 196 participants, and expect to complete enrollment in the fall of 2016. The long-term goal of this line of research is to establish a home-based monitoring system to identify patients at risk for dehydration who can benefit from early intervention, thus preventing unnecessary hospital and emergency room (ER) admissions. R01: #zzzzz

Past Projects

CYCORE: CYberinfrastructure for COmparative effectiveness Research
(Project Dates: 9/30/2009 – 8/31/201, RC2CA148263)

The original CYCORE grant was a National Cancer Institute ARRA-funded Grand Opportunity (GO) research project to improve cancer therapies by developing better tools to measure their effectiveness in clinical trials.

The purpose of this grant was to design and validate, within a community of cancer investigators and patients, a prototype cyberinfrastructure (CI) that supports the acquisition, storage, quality assurance, visualization, analysis, and sharing of clinical, genetic, physiologic, and behavioral data for cancer-related trials. One of the key areas to be addressed in CYCORE is how to collect behavioral and social data relevant to cancer outcomes from free-living individuals in their homes and communities. Thus, a major component of this project is exploring the use of wearable sensors linked to home-health communication hubs so that information can be gathered and integrated into comparative effectiveness research studies alongside clinical and other data.

Principal Investigators, M.D. Anderson Cancer Center: Susan Peterson, PhD, Karen Basen-Engquist, PhD, and Alex Prokhorov, MD

Principal Investigator, UCSD/Calit2: Kevin Patrick, MD, MS

Investigators, UCSD/Calit2: Ingolf Krueger, PhD, Chaitan Baru, PhD, Emilia Farcas, PhD, Doug Palmer, PhD, Phil Rios